Big exchanges and some regulation may not be a negative thing. Look at it this way: If there is some form of regulation that allows for funds to sink monies into these coins, that equals more inflows. Imagine an ETF for these coins or a mutual fund being able to take some ownership? That would be serious inflows. Won't happen without some sort of standard out there for these coins. As bitcoin grows, if it grows, you will see all of these entities wanting to get a piece of the pie. This could include exchanges similar to NASDAQ who may want to diversify, but that would require more stability or regulation. I think any and all opportunity is good opportunity. Also, buy and hold will help make this coin go up. Moreso than mine and hold. Mining simply increases the float, but still not a bad thing. Cryptsy needs seed funding similar to coinbase. They need to grow infrastructure big time. I would be surprised if we do not hear that happen soon if they are smart.